Zingiber Officinale is a common condiment for various foods and beverages and a long history of important Traditional Medicine herb for the treatment of stomach disorders. The constituents present in ginger have potent antioxidant and anti-inflammatory activities. The study deals with antimicrobial activity of Zingiber Officinale (ZO) extract and their phytochemical composition. Phytochemical screening revealed the presence of alkaloids, saponins, tannins, flavonoids, terpenoid and phlobotannins in both the extracts. The GO extracts were obtained by sokhlet apparatus and their chemical profile was determined through GC and GC-MS analysis resulted in the identification of 40 compounds in methanolic and 32 compounds in ethanolic extract. Their antimicrobial activity was tested against nine microorganisms that cause various diseases in human. Zingiber extracts showed selective antimicrobial activities. _____________________________________________________________________________________________