In the present study, the wound-healing activity of some substituted hydroxytriazenes was investigated. Excision, resutured incision and dead space wound models were used to evaluate the wound-healing activity of substituted hydroxytr iazenes. In excision wound model, treatment was continued till the complete healing of the woun d, in incision and dead space wound models the treatment was continued for 10 days. For topica l application, 5% w/w ointment of hydroxytriazenes was prepared in 2% sodium alginate and for oral administration hydroxytriazenes dissolved in DMSO, at dose 5 mg/kg were used. In excision and incision wound models, the control group of animals was left untreated and in dead space wound models the animals were treated with DMSO (1ml/kg). The he aling of the wound was assessed by the rate of wound contraction, period of epithelialisat ion, skin breaking strength, granulation strength, dry granulation tissue weight and hydroxy proline estimation. Except the parent compound (HD-1), rest of the hydroxytriazenes (HD-2 and HD-3) significantly promoted the wound-healing activity in all the three wound model s. Substituted hydroxytriazenes (HD-2 and HD-3) promote the wound-healing activity, whereas t he parent hydroxytriazene compound (HD- 1) does not do so.