Wounds are subjected to infection of many microorganisms, so many antimicrobial agents are used to treat these chronic wounds. Wafers are being developed as drug delivery systems that can be applied directly to the surface of suppurating wounds. These wafers instantaneously adhered to the surfaces, absorbing water and transforming from glassy, porous solids to highly viscous gels. Wafers were characterized for morphology, mechanical and in vitro functional (swelling, adhesion, drug release in the presence of simulated wound fluid) characteristics. The optimized dressing has the potential to reduce bacterial infection and can also help to reduce swelling and pain associated with injury due to the anti-inflammatory action and help to achieve more rapid wound healing. Polymer-drug interactions and physical form were characterized by Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD), respectively, while morphological structure was examined using scanning electron microscopy (SEM). Functional characteristics (mechanical hardness and adhesion using texture analyzer, and swelling capacity) of blank wafers were determined in order to select the optimal formulations for drug loading. Finally, the in vitro drug dissolution properties of two selected drug loaded wafers were investigated. Many wafers are also used in cancer treatment and their toxicity is reported. The new innovative studies of the wafers gives an over view which is used to treat Corneal Cystinosis and also to treat dry eye in order to restore healthy corneal surface. This review helps to outline the novelty of the wafer in the future development of pharmaceutical dosage forms.