Original Articles: 2018 Vol: 10 Issue: 3
Valsartan Fast Dissolving Tablets: Formulation and In vitro Characterization
Abstract
Back ground: Valsartan as an angiotensin II receptor antagonist widely used in the management of hypertension. Aim: The present research work was aimed to develop a fast dissolving tablet (FDT) of Valsartan. Methodology: The FDT was formulated using different concentration (1, 2, and 4 %) of superdisintegrants like croscarmellose sodium, crospovidone, sodium starch glycolate and PVP K-30, using Avicel PH -102 using as diluents. The drug excipients interaction was examined by using FTIR and DSC. The drug excipient blend was examined for flow properties. All the batches of FDT were prepared by direct compression method and were evaluated for weight variation, hardness, friability, wetting time, water absorption ratio, disintegration time, dissolution study, in vitro drug release kinetics and stability study. Results and discussion: FTIR and DSC studies showed no evidence of interactions between drug and excipients. The IPQC parameters evaluation results for FDT for all batches were found to be acceptable according to standard limits of I.P. From the data of regression R2, it was concluded that optimized formulations followed first order drug release kinetic. Amongst all FDT formulations, formulation F8 prepared by using drug with 2% Crospovidone showed least disintegrating time of 21±0.31 s and greater dissolution (100.38 %). Conclusion: From the above studies, it was concluded that fast dissolving tablet of Valsartan prepared by crospovidone as superdisintegrant is most acceptable for safe management of hypertension.