Simple, sensitive, accurate and precise zero order (methods A & B) and first order derivative (methods C & D) spectrophotometric methods have been developed and validated for the individual assay of cefpodoxime (methods A & C) and cefprozil (methods B & D). The zero order (methods A) and first derivative (methods C) spectrophotometric methods were used for the determination of cefpodoxime in the range of 10-50 μg/ml by measuring the absorbance at 234 nm and 222 nm respectively. The measurement of absorbance at 230 nm and 223 nm was used for the assay of cefrozil by the zero order (methods B) and first derivative (methods D) spectrophotometric methods in the range of 10-50 μg/ml. The developed methods were validated according to the guidelines given by International Conference on Harmonization and proved to be sensitive, robust, precise and accurate for the quality control of the selected drugs in their tablet dosage forms.