Novel pyridine derivatives were synthesized by reaction of chalcones 4(a-e) with different acetyls 5(a, b) under microwave irradiations or under reflux conditions. In general, microwave irradiation offered the advantages of high yields, short reaction times, and simplicity compared to the conventional methods. The structures of all the compounds were confirmed by analytical and spectral data. Some of The synthesized compounds were evaluated against HepG-2, and showed significant antitumor activities.