A microencapsulation study of verapamil hydrochloride with biopolymer polycaprolactone (PCL) as coating material using emulsification solvent evaporation method (W/O) has been carried out. Variations comparison verapamil hydrochloride with polycaprolactone were 1: 1, 1: 2, 1: 3 for each speed of stirring 400 rpm, 700 rpm and 900 rpm. Span 80 was used as the emulsifier. Microcapsules were characterized by X-ray diffraction (XRD), Scanning Electron Microscopy (SEM), Fourier Transform Infra-Red (FTIR), particle size distribution and dissolution profiles. The results showed, the microcapsules were spheric with sizes range between 10 – 30μm. The dissolution profiles showed a decrease in dissolution rate compared to the active substance microcapsules verapamil hydrochloride. The highest encapsulation efficiency was 72.42% for F9 (formula 9) with a ratio of 1: 3 (verapamil HCl: PCl) with stirring speed of 900 rpm. Statistical analysis using Annova one direction between the active substance verapamil hydrochloride and microcapsules with the percent dissolution efficiency showed a significant different results compared to the active substance. In conclusion, the greater the number of PCL coating is used, the greater the inhibition of the release of verapamil hydrochloride from microcapsules. Release kinetics model of verapamil hydrochloride from microcapsules followed the Langenbucher equation.