Tumor microenvironment plays a key role in regulating tumorigenesis, progression, and metastasis of cancer. Although it is well investigated the interactions between cancer cells and tumor microenvironment, many mechanisms still retain unknown. In the last several years, Chinese scientist achieve many accomplishment in tumor microenvironment research field refer to tumor immune escaper and anti-tumor immunity; angiogenesis, lymphangiogenesis and tumor therapy; epigentics and tumorigenesis; proliferation, angiogenesis, invasion and metastasis of cancer; cancer cell, stromal cells and their chemokines or cytokines; the molecular mechanisms of cancer invasion and metastasis. Especially, the molecular mechanism has been well elucidated in epigenetics of breast cancer and anti-angiogenesis, anti-lymphangiogenesis by Endostatin and VEGI (TNFSF15).