Topical therapies for nail diseases are limited by keratinized cells in human nail plate. Current research on nail permeation focuses on altering the nail plate barrier by means of chemical treatment and penetration enhancers. Fungal nail infection is a common problem affecting around 3 in every 100 people in the UK. Onychomycosis is a fungal infection of the nail bed or nail plate that is difficult to treat since it is chronic. Onychomycosis occurs in the elderly people rather than in children, it is responsible for approximately 50% of all nail disorders and affects 14% of the population. Nail lacquers have been used as cosmetics since a long time for beautification and protection of nails. Convenience, sustained release and first pass avoidance are most often cited among the benefits. In this review we are trying to focusing on transungual drug delivery of antifungal drugs, through using penetration enhancers novel therapy for the treatment of nails.