An eco-friendly, facile and efficient approach for the diastereoselective synthesis of differently substituted trans-2,3- dihydrofuro[3,2-c]coumarins is described. The method is based on the use of α-tosyloxyketones as a precursor and ultrasonic irradiation as a source of energy and ionic liquid [BMIm]OH, which functions both as a catalyst and the reaction medium for the synthesis of trans-2,3-dihydrofuro[3,2-c]coumarins. The developed protocol provides a better alternative to the existing methods as it involves utilization of α-tosyloxyacetophenones avoiding the use of α- haloacetophenones.The antifungal and antibacterial evaluation of the title compounds 4a-4l is also described