This review examines the therapeutic potentials and mechanism of action of nitric oxide releasing non-steroidal anti-inflammatory drugs. NO-releasing NSAIDS markedly improve the anti-inflammatory and antinociceptive actions efficiently and diminish gastrointestinal toxicity. The nitric oxide releasing NSAIDS may be useful to treat wide variety of diseases like colitis, cancer, thrombosis, restenosis and bronchial asthma.