AGPAT2, 1-acylglycerol-3-phosphate-o-acyltransferase2 (also known as lysophosphatidic acid acyltransferase, is a novel target for cancer therapy. There are several lysophosphatidic acid acyltransferase inhibitors. In this work different QSAR models are developed using quantum chemical parameters like HOMO, LUMO, dipole moment etc and also with topological indices like Wiener index, Harary index etc. The models are examined and it is found the model containing both electronic parameters and topological indices are suitable for screening these inhibitors which may also give an idea for initiating new inhibitors