Cyclodextrins are cyclic oligosaccharides which have recently been recognized as useful pharmaceutical excipients. The molecular structure of these glucose derivatives, which approximates a truncated cone or torus, generates a hydrophilic exterior surface and a non polar cavity interior. As such, cyclodextrins can interact with appropriately sized molecules to result in the formation of inclusion complexes. These non-covalent complexes offer a variety of physicochemical advantages over the un manipulated drugs including the possibility for increased water solubility and solution stability. Further, chemical modification to the parent cyclodextrin can result in an increase in the extent of drug complexation and interaction. In this short article, the effects of substitution of paracetamol in α, β & γ cyclodextrin and the forces involved in the drug-cyclodextrin complex formation are discussed. Some general observations are made which predict that γ complexes are most stable than β complexes which are more stable then α complex.