The aim of this reasearch is to investigate the effects of various extracts of Tongkat Ali on uric acid excretion and renal function in rats with hyperuricemia. Sprague dawley male rats were fed with yeast extract, adenine and potassium oxonate to make the model of rats with hyperuricemia. With the animal model being made, Rats were given various extracts from Tongkat Ali for 14 d. Then, uric acid(UA), urea nitrogen(UN), creatinine(Cr) levels in serum and urine and the activity of Xanthine oxidase (XOD) in serum and liver were measured. The level of serum uric acid in the chloroform group and n-butanol group was lower than that in the model group (P<0.05). The uric acid and creatinine levels of urine in the chloroform group and n-butanol group was higher than those in the model group (P<0.05). Besides, the activity of XOD in chloroform group and n-butanol group was lower than those in the model group(P<0.05). Chloroform and n-butanol extract from Tongkat Ali can reduce the level of serum uric acid in rats with hyperuricemia which were induced by adenine, yeast extract and potassium oxonate. This function may be produced through inhibiting the activity of Xanthine oxidase.