Widespread overuse of antibiotic as paved the way for the development of resistance, diseases which were once upon a time easily curable has become one major concern of the world. Microorganism like bacteria can quickly adapt itself against the action of the antibiotic which makes it difficult to kill them. Multidrug resistance in gram positive and gram negative bacteria becomes very difficult to treat with conventional antibiotics. Since it is very time consuming and expensive to come up with new antibiotics, scientists are trying to come up with new methods like bacteriophage therapy, vaccinations, etc. This reduces the chance of development of resistance and minimises the use of antibiotics.