With the development of China’s economy and the evolution of medical insurance system, bio-pharmaceutical has become an industry experiencing rapid development. In this situation, it is of great importance to evaluate the growth ability of bio-pharmaceutical listed companies in order to boost its stable growth. The concepts of factor analysis and entropy method are first defined in the first part. Then, this paper explores the key factors that affect the growth capacity of Chinese bio-pharmaceutical listed companies most by using factor analysis and entropy method. As a result, these influential elements can be summed up as growth equality factor；risk factor；growth efficiency factor and innovation factor. Finally, some reasonable suggestions are presented to escort the sustainable development of Chinese bio-pharmaceutical listed companies .