The aim of this research was to compare the effect of pyridine and triethylamine catalyst ratios on the synthesis of 2-phenyl-benzo(d)[1,3] oxazine-4-one derivatives. The catalysts used were triethylene amine (100%), pyridine: triethylamine (1: 4 mol); Pyridine: triethylamine (1: 1 mol) and pyridine (100%). Using pyridine (100%) as a catalyst could increase the percentage of the synthesis of 2-phenyl-benzo[d][1,3] oxazine-4-one derivatives to 2 times greater than pyridine: triethylamine (1: 4 mol) as a catalyst. Using pyridine (100%) as a catalyst in the synthesis of 2-phenyl-benzo[d] [1,3]oxazine-4-one derivatives were more effective and efficient by obtaining the following results we obtained 80% for 2-phenyl-4H-benzo[1,3]oxazin-4-one and 86% for 2-(3,4-dichlorophenyl)-4H-benzo[1,3]oxazin-4-one and 82% for 2-(2,4-dichlorophenyl)-4H-benzo[1,3]oxazin-4-one and 46% for 2-(4-nitrophenyl)-4H-benzo[1,3]oxazin-4-one.