The success of any health care industry depends on three important parameters i.e. quality, safety and efficacy. The quality improvement became every ones challenge and the department of quality control and quality assurance came in to the picture very recently. Due to globalization and increased competition, every health care sector focus is on to maintain quality which is an important factor and controls the other factors known as safety and efficacy which in turn produce the zero defect product. However there are many challenges or failures to produce this zero defect product and inorder to rectify these failures and challenges, the implementation of quality management is very important in every industry, The success of quality management will depends on implementation of Total Quality Management, Six Sigma, Change Management/ Change control/ Deviation Management, Out of Specifications (OOS), Out of Trend (OOT), Corrective & Preventive Actions (CAPA). Hence this current review is emphasizing on importance of implementation of above quality management principles based on the published case studies.