Various parts of Malva sylvestris have different medicinal properties such as antimicrobial activity. In this study the effects of M.sylvestris extract on protein electrophoresis pattern and gamma interferon of C.albicans infected mice was studied. Sixty female mice were divided randomly in six groups (three treatment groups, Candida, placebo, and control groups). Treatment groups received aquatic extract of M.sylvestrs (50,100 and 200 mg/kg) for 20 days every other day via injection in peritoneum. C.albicans was injected once after sixth injection of extract. Results showed significant decrease in the amount of albumin in three treatment groups. β-globulin amount of 50 and 100 mg/kg groups and gamma interferon amount of all three treatment groups were increased significantly in proportion to control group. Clearing the body from pathogen organisms depends on cellular responses. It seems that M.sylvestris is capable of stimulating cellular immune response and can be used in studies about C.albicans