The objective of this study was to study the anti-rheumatic effect of the aqueous extract of Inula viscosa in arthritic rats. Male albino Wistar rats (40) weighing 180 to 190 g were selected and divided into five groups, maintained eight rats in each group. Groups 1 and 2 were served as normal and arthritic control. Group 3 was treated with standard drug as B-métasone 0.30 mg/kg body weight, whereas groups 4 and 5 were administered extract of 100 and 200 mg/kg body weight, respectively. arthritic was induced by using vitamin A in rats. Treatment was carried out for 6 months and the fasting serum phosphatase alkaline, CRP, calcium and urinary pyridinolines were measured. Data was collected and analysed statically using one-way analysis of variance (ANOVA) followed by Student’s t-test. The statistical data indicated the significant decrease in the fasting serum pyridinolines level. In arthritic rats, phosphatase alkaline, CRP and calcium of arthritic rats also decreased. The aqueous extract of Inula viscosa has shown anti-rheumatic effect in vitamin A induced arthritic rats.