The objective of this study was to investigate the inhibition of antibacterial and antioxidant activity by extracts of the aerial parts of Azorella multifida collected in Cuenca, Ecuador. Azorella multifida presented poor antioxidant activity in dichloromethane and petroleum ether extracts (DPPH) with IC50 values >300 ug/mL, while it showed moderate antioxidant activity in methanolic extracts. Total phenolic content was determined using Folin-Ciocalteu method and total flavonoid content by the formation of a flavonoid-aluminum complex. All extracts were evaluated as antibacterial agents on clinical isolates of human pathogens without demonstrating activity on the microorganisms. Antibacterial activity against phytopathogenic microorganisms was evaluated, with interesting results.