Metals are essential cellular components selected by nature to function in several indispensable biochemical processes for living organisms and possess good antibacterial activity. For present study we selected an herbal origin drugs such as Gallic acid, Quercetin, Catechin. In this work, we had synthesized the complexes of selected drugs with bismuth using its two different salts such as bismuth nitrate and bismuth citrate at neutral ph. The method of synthesis was further standardized in order to optimize the yields of title compounds, by altering one parameter at a time and keeping others constant. Purification of title compounds were done by multiple washing with solvents such as water, ethanol. The title compounds were characterized by Uv visible spectroscopy, IR spectroscopy, Elemental analysis, Inductively coupled plasma atomic emission spectroscopy (ICP-AES), Differential scanning spectroscopy and XRD analysis. Molar absorptivity ratio was determined, which indicates 1:1 formation of drug and metal complex. Karl Fischer analysis for synthesized complexes showed smaller percentage of water which indicated the fact of presence of coordinated water molecule with active molecule. To evaluate the changes in microbiological activity of parent drug after complexation, antibacterial studies were carried out by observing the changes in MIC (minimum inhibitory concentration) of the complexes and compared with that of parent drug. Our investigations reveal that formation of complexes results in increase in antibacterial activity of parent drugs and MIC values are decreased.