Some new transition metal complexes of Co(II), Zn(II) and F(III) with amoxicillin and cephalexin were prepared. The complexes were characterized based on melting point, solubility, conductivity, elemental analysis , IR and UV/Visible spectroscopy. Based on the data obtained, the complexes were proposed to have the formulae [M(A)(B)] where M= Co(II), Zn(II) , Fe(III) ; A= amoxicillin and B = cephalexin. The anti-microbial activities of the complexes / ligands using disc diffusion method was screened against different strains of bacteria; Staphlycoccus aureus, Strep pyogene, Bacillus subtilis, E.coli, Salmonella shigella, Klebsiella pneumonia, Pseudomonas auroginosa .The IR spectra indicates that both ligands A and B coordinated to the metal ion via v(C=O), v(O-H) and v(N-H) respectively. The UV/Visible electronic spectra further revealed that Co(II) and Fe(III) complexes are octahedral while that of Zn(II) is tetrahedral. The complexes melted/decomposed at (200-280)◦C. They are soluble in polar organic solvents. Anti-microbial activity studies, revealed that Co(II) complex showed increased activity against the tested organisms while Zn(II) and Fe(III) showed decreased activity as compared with the ligands.