KF-alumina catalyzed condensation of 6-amino-3-methyl-1-phenyl-1H-pyrazolo[3,4-b]- pyridine-5-carboxamide with cyclic ketone and aryl or alkyl ketones to provide spiro pyrazolo[4′,3′:5,6]pyrido[2,3-d]pyrimidine and pyrazolopyridopyrimidines derivatives respectively.