Variety of 2-amino-3-cyano-4-aryl-6-(1-napthyl amin o)-pyridines 3(a-h) have been synthesized by reacting 1-(1-napthyl amino)-3-aryl-2-propen-1-o nes 2(a-h) with malononitrile and ammonium acetate in methanol under reflux condition . Structures of the synthesized compounds were confirmed by the spectral analysis. Furthermor e, all the synthesized products were screened for their antibacterial activity.