Novel series of benzo-oxazole derivatives were prepared by the condensation of 4- methyl sulfonyl acetophenone with various benzamide. The structures of the synthesized compounds were VI1-Vl3 assigned on the basis of elemental analysis, IR, 1H NMR and mass spectroscopy. These compounds were screened for anti-inflammatory activity having asignificant anti-inflammatory activity when compared to the reference anti-inflammatory drug celecoxib using Invivo and Invitro anti-inflammatory screening