In the present study two series of novel 4-(4-methylthiobenzyl)-5-oxo-7-(5-aryl-2-furfurylidene/arylidene)-1,2,4- triazino[3,4-b]-thiazole-6-ones were synthesized by the multi component reaction of 6-(4-methylthiobenzyl)-3- mercapto-1,2,4-triazin-5(4H)-one with chloroacetic acid and 5-aryl furfurals/aromatic aldehydes in presence of acetic anhydride and sodium acetate in acetic acid media. The structures of the newly synthesized compounds were characterized by spectral studies. New compounds were screened for their anticonvulsant(Pentylenetetrazole animal model) and antimicrobial activity. Compound 4c and 4d exhibited considerable anticonvulsant effect on animals by protecting them for a longer duration.