A series of novel 3-methyl-2-4-(1-H-pyrrol-1-yl-phenylimino)–thiazolidin-4-ones and 3-ethyl 2-4-(1-H-pyrrol-1-yl-phenylimino)–thiazolidin-4-ones derivatives were synthesized and were tested for their antibacterial and antifungal activities. These compounds showed moderate in vitro activities against the microorganisms tested.