Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

header
Reach Us reach to JOCPR whatsapp-JOCPR +44 1625708989
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Original Articles: 2016 Vol: 8 Issue: 4

Synthesis of N-(2-nitrophenyl) pyrazine-2-carboxamide and N-(4-nitrophenyl) pyrazine-2-carboxamide and evaluation of their antimycobacterial properties using in vitro and in-silico techniques

Abstract

N-(2-nitrophenyl) pyrazine-2-carboxamide and N-(4-nitrophenyl) pyrazine-2-carboxamide synthesized and studied as an anti-tuberculosis agents using in-silico and in-vitro analysis. In-silico study reveals the inhibition of Mycobacterium tuberculosis mycolic acid cyclopropane synthase CmaA2 (PDB Code : 3HEM) by both compounds. Whereas in-vitro study, reveals the inhibition of M. tuberculosis H37Rv occurred at concentrations ≥32 μg/ml for n- (2-nitrophenyl) pyrazine-2-carboxamide only.

http://sacs17.amberton.edu/

rtp slot demo