Synthesis of hydroxyapatite(HAp), CA10(PO4)6(OH)2, using cockle shell (Anadara granosa) as a source of calcium has been carried out using a hydrothermal method through three routes, namely: direct synthesis of powdered shells; synthesis through the process of thermal decomposition powdered shells and synthesis through the formation of Precipitated Calcium Carbonate (PCC) of the shells. HAp synthesized result has been analyzed using X-ray Diffraction (XRD), scanning electron microscopy (SEM) and Fourier Transform Infrared Spectroscopy (FTIR). The analysis result of the synthesis product has been obtained that HAp ceramic synthesis through the formation of PCC gives the best results, which is in the synthesis conditions 16 hours at a temperature of 140oC.