Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2015 Vol: 7 Issue: 10

Synthesis of a combined prodrug of albendazole and metronidazole

Abstract

The treatment of hydatidosis is primarily surgical but can cause morbidity or mortality, hence the int erest in many cases of medical treatment whose main representativ e is albendazole. The efficacy of this compound aga inst Echinococcus granulosus cysts is proved, but limite d by its poor bioavailability. Some prodrugs of alb endazole have been described but no bioavailability study has sho wn their interest to present. The new a combined pr odrug of albendazole and metronidazole was synthesized. The compound thus prepared was characterized by this ph ysical (TLC) and spectral data (ESI-MS).

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