New novel derivatives of 1-(4-subtetude methyl/meth oxy /chloro/bromo/nitro/phenyl)-3-(5-((3-(4-triflur omethyl phenyl)-4-(thiomorpholine/4-methyl piperazine / mor pholin -4-yl) methyl)-3,4dihydroimidazo (4, 5-b) in dol -2yl) methyl)-2-oxo-2H-1, 3, 2-benzo Dioxaphosphol-2-yl) urea. 9(a-l) as depicted in scheme: I.1 were prepar ed by condensation reaction between 4-(4-(thiomorpholino / morpholinomethyl / 4 - methylpiperazin) -3-(4- (trifluoromethyl) phenyl)-3,4-dihydroimidazo[ 4,5-b ] indol-2-yl) benzene-1, 2-diol 7(a-c) and Phenyl corbomylphosphoramidic dichloride 8(a-f). The synth on 7(a-c)was obtained by mannich reaction of 4-(3- (4- (trifluoro methyl) phenyl) -3,4-dihydroimidazo[4,5- b]indol-2-yl)benzene-1,2-diol (5) with different se condary amines having hetero atomin cyclic ring and HCHO 6( a-c) in presence of DMF. The synthon (5) was obtain ed by condensation reaction between 4-(((4-(trifluorometh yl) phenyl)imino)methyl)benzene-1,2-diol(3) and Isa nti (4). The Synthon (3) was synthesized by reaction between 3, 4-dihydroxy benzaldehyde and 4-(trifluorometyl) ani line.The procedure was characterized by IR, 1 H-NMR, 13 C-NMR, 31 P-NMR and elemental analysis. The newly synthesized compounds were subjected to various biological acti vities and docking studies.