A novel series of 2-N-(aryl substituted)-4-methyl-6-phenylpyrimidine-5-carboxylic acid(5a-m) were synthesized from ethyl2-N-(aryl substituted)-4-methyl-6-phenylpyrimidine-5-carboxylate(4a-m). The structures of these compounds were established on the basis of spectral and analytical data. These novel compounds were screened for their antibacterial activity. Among them compounds 5a, 5b, 5g, 5h, 5k, 5l and 5m have shown significant activity.