Derivatives and their complexes from the ciprofloxacin fluoroquinoline family were synthesized, tested for antibacterial activity.The structure of derivative and their complex shows good antibacterial activity for the diagnostic aspects. Several reports have highlighted the interest of increasing the lipophilicityto improve the antitumor efficiency (2).These studies have led us to synthesize ciprofloxacin derivatives and to evaluate their activity by complex formation with metal ions. With an easy and cost-efficient procedure, derivatives of ciprofloxacin were prepared and yield had excellent .FTIR,Element Analysis, NMR analysis has been used to characterize the newly isolated complexes. This thesis intends to combine ciprofloxacin with metal ion, with the aim to improve the antibacterial activity. TheFTIR spectra of the isolated complexes suggest that ciprofloxacin derivative is act as bidentate ligands through the ring carbonyl oxygen atom and one of the oxygen atoms of the Carboxylic group. Derivative 06 showed enhanced activities than ciprofloxacin against all gram-positive and gram negative organisms likewise 2 & 5 showed highest activity against Pseudomonas spp. moreover 2 exhibited better activity against Salmonella spp, Salmonella typhi, Salmonella typhi Para-A, Salmonella typhi Para-B and Shigalla dysenteriae.