The Mannich base -N-[1-morpholino-4-methyl benzyl]-benzamide was synthesized by reported method and characterized by elemental analyses, I.R. and NMR spectral data. The complexes of the Mannich base with a number of transition metals were prepared and characterized by elemental analyses, molar conductance, mangentic susceptibility, electronic, IR and NMR spectral studies. TGA was also performed in a number of complexes. The biological screening of the Mannich base and few of metal complexes was also carried out