Synthesis of various (N-(2-chloro-4-(trifluoromethyl) phenyl)-4-(substitutedphenyl)-1,2,3,4-tetrahydro-6-methyl-2- oxopyrimidine-5-carboxamide 3(a-o) from N-(2-chloro-4-(trifluoromethyl) phenyl)-3-oxobutanamide, Substituted benzaldehydes and urea in presence of Conc.HCl. The structures of the synthesized compounds were confirmed on the basis of spectral and elemental analysis. The synthesized compounds were screened for antimicrobial activity.