A novel Schiff’s base derivatives were synthesized from some substituted Indole-3-carbaldehyde with substituted 2-aminothiazole. Which was 2-amino Thiazole synthesized by substituted phencyl bromide and thiaourea. All the synthesized compounds were confirmed their structures by elemental analysis, 1H NMR, 13C NMR, Mass spectral data and also studied their biological activity.