A simple and efficient synthesis of 2-(4-methyl-7-hydroxy-coumarin) -4-(4-Flouro-3-Choro-amino)-6-(arylamino)-striazine have been synthesized. The novel compounds structure has been established on the basis of their substituted aryl amine derivatives. All the compounds were characterized by FT-IR, and 1H-NMR spectroscopy as well as elemental analysis. These new compounds were evaluated for their in vitro antibacterial activity.