Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2010 Vol: 2 Issue: 1

Synthesis, characterization and biological activity of metal complexes of 3-amino-5-methyl isoxazole Schiff bases

Abstract

Metal chelates of biologically important Schiff bas es namely 4-methyl-2-{[(5'-methyl-3'- isoxazolyl)imino] methyl} phenol ( MEMIIMP) and 5-methoxy-2--{[(5'-methyl-3'- isoxazolyl)imino] methyl} phenol ( MMIIMP) with Cu(II), Ni(II), Co(II), Zn(II) and VO( IV) have been synthesized. The metal chelates have been char acterized by elemental analysis molar conductivity data TG, DTA, spectral (IR, 1 H-NMR, Mass, ESR and electronic) and magnetic moments. The dissociation constants of Schiff bases and stability constants of Cu(II), Ni(II), Co(II) and Zn(II) complexes have been determined po tentiometrically in aquo organic medium at 30±1 o C and at 0.1 M KNO 3 ionic strength. Antimicrobial activities of Schiff bases and their complexes were screened against bacteria & fungi ar e discussed.

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