Synthesis of a new series of [5-(1H-indol-3-yl)-3-phenyl-4, 5-dihydropyrazol-1-yl]pyridin-3-yl methanone derivatives (3a-3g) by the reaction of nicotinic acid hydrazide with various indolyl chalcones (2a-2g) has been described. The indolyl chalcones have been synthesized from indole-3-carboxaldehyde and different substituted acetophenones. The structures of these compounds are confirmed by physico-chemical as well as IR, 1H NMR, 13C NMR and Mass spectral means. The synthesized compounds are screened for their in-vitro antibacterial potentials against various strains of bacterial organisms. Minimum inhibitory concentration (MIC) and minimum bactericidal count (MBC) have been determined for the compound 3c, which showed good anti bacterial activity