Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2010 Vol: 2 Issue: 5

Synthesis, characterization and biological activity of 1, 3-thiazolidin-4-one derivatives of 2-mercapto-5-methyl-1,3,4-thiadiazole

Abstract

As a part of systematic investigation of synthesis and biological activity of several new 2-[2- (Substituedbenzyliden)hydrazinoacetyl]-mercapto-5-methyl-1,3,4-thiadiazole, 3(a-n), 2-[2-{2- (substitutedphenyl)-4-oxo-1,3-thiazolidin}–acetylimino]-mercapto-5-methyl-1,3,4-thiadizole, 4(a-n) and 2-[2- {2-(Substitutedphenyl)-4-oxo-5-(substitutedaryliden)-1,3-thiazolidin}-acetylimino]-mercapto-5-methyl-1,3,4- thiadiazole, 5(a-n) have been synthesized from 2-(2-hydrazinoacetyl)-mercapto-5-methyl-1,3,4- thiadiazole, 2 using 2-mercapto-5-methyl-1,3,4-thiadiazole as the starting material. All the synthesized products were evaluated for their and antibacterial activity against B. substilis, E. coli. K. pneumoniae and S. aureus bacteria and antifungal activity against A. niger, A. flavus, F. oxisporium and T. viride fungi respectively. The structures of all the synthesized compounds have been determined by their spectral and microanalytical data.

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