Schiffbase complexes of the Cu(II),Ni(II), and Co(II) 4-pyridine carboxaldehyde 3-amino pyridine complexes were synthesized and characterized by elemental analysis ,magnetic susceptibility, conductivity measurements, FT-IR, electronic, spectral measurements, XRD studies antimicrobial and nuclease activity studies. The conductance measurements indicate that all the complexes are non-electrolytes. The IR spectra indicate the coordination of pyridine nitrogen and M-N bonds .The powder XRD analysis indicates that the complex is nanocrystalline. The results indicate that all the above mentioned metal ions are hexacoordinated and having moderate antimicrobial and nuclease activity.