The Mannich base -N-[1-morpholinobenzylacetamide] and its transition metal complexes with Ti (III), V (III), Mn (III), Fe (III), Co (III), MoO(V), Ru (III), Ru (II), MoO2 (VI) and UO2 (VI) have been synthesized. The ligand and its metal complexes have been characterized by M.P., elemental analyses and spectral studies. The ligand and the corresponding metal complexes were screened for their antibacterial activities.