Novel Cu(II), Mn(II), Fe(II) and Zn(II) metal complexes of Schiff bases were synthesized from the condensation reaction between salicylaldehyde and aniline (L1) and sulphadiazine (L2) and characterized by FTIR and UV-Visible spectroscopy. Conductivity, melting point and solubility measurements were also carried out. It was observed that these complexes were non-toxic, non-electrolytic and stable solids. The IR and results showed that the involvement of the azomethine nitrogen in coordination with the metals. The complexes were also screened against various microorganisms; they showed strong potency against the micro-organisms.