We wish to report here with synthesis of bis-schiff bases via condensation of hydrazone of 2-hydroxy acetophenone with different substituted acetophenone in presence of SnCl2 as a catalyst just by grinding to accomplish the bisschiff base with moderate to good yields. All the synthesized Schiff bases were analyzed by spectral analysis IR, 1H NMR and Mass spectrometry. All these bis-Schiff bases were screened for antimicrobial activity by using Agar Disc Diffusion method