This paper discuss a series of Meldrum acid derivatives and 4- quinolone,4-chloroquinoline derivatives which demonstrate a wide range of biological activity. In the present investigation Meldrum acid is taken as starting material and treated with different aromatic amines afforded Phenylamine(methylene Meldrum's acid)derivatives, Which further cyclazation in diphenyl ether yielded 4-quinolone derivatives. The quinolone derivatives reacted with (POCl3) gives substituted 4-chloro quinoline. Some of The synthesized compounds were characterized by FT-IR, 1H-NMR and C13-NMR, Some the synthesis compounds were screened in vitro antimicrobial for biological activity.