We report here the synthesis of some new pyrimidin-2-amines and their anti-inflammatory activity against Balb/c mice with locally induced edema. Spectral characterization of the compounds is explained. The better drug candidate is optimized among the tested compounds. Of the synthesized compounds, 4-(9H-Fluoren-2-yl)-6- phenylpyrimidin-2-amine and 4-[4-(Diphenylamino) phenyl]pyrimidine-2-amine are found to have more efficient anti-inflammatory activity than that for 4,6-Bis-(9H-fluoren-2-yl)pyrimidin-2-amine and 3-[3-(9H-Fluoren-2-yl)-3- oxoprop-1en-1-yl]-4H-chromen-4-one.