The aim of the present work is to synthesize some Schiff base complexes of metal ion and to evaluate their antimicrobial activities. A New Schiff base has been derived From 1,2-diacetyl benzene and 4,5-dimethyl -O- Phenylenediamine and their Complexes with Cu(II), Co(II), Ni(II) have been synthesized and evaluated for their antibacterial activities by disc diffusion method. The complexes have been characterized by conductance, magnetic, IR and electronic spectroscopic techniques.