A new Mannich base, N-(morpholino-N, N-dimethyl-4-aminobenzyl) benzamide, formed by the condensation of morpholine, benzamide and N, N-dimethyl-4-amino benzaldehyde and its Fe(II), Fe(III), Mn(III),Co(III),Ti(III),V(III),V(IV),MoO(V),Ru(II) and Ru(III) complexes haνe been Synthesized. Their probable structures have been proposed on the basis of their microanalytical, IR, UV-νis. 1H NMR spectral data. All the complexes exhibit octahedral geometry. The biological activities of the ligand and its metal chelates against the bacteria E.coli, Staphylococcus aureus, Klebsiella pneumonia, Salmonella typhi, Pseudomonas aeruginosa and Shigella flexnri are also being reported. The complexes have higher activity than that of the free Mannich base and the control.