Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

header
Reach Us reach to JOCPR whatsapp-JOCPR +44 1625708989
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Original Articles: 2015 Vol: 7 Issue: 10

Synthesis and identification of some derivatives of 1,3,4-thiadiazole

Abstract

This research involved synthesis heterocyclic compo unds such as (1,3,4- thiadiazole derivatives , imid azolidine derivatives, tetrazole derivatives, oxazepine deriv atives and β -Lactam derivatives ) were prepared by reaction 4- aminobenzoic acid with phenol in Acidic medium ,(0- 5)C O and sodium nitrate to get azo derivative (1) which react with thiosemicarbazide to get 1,3,4- thiadiazole de rivative (2). Derivative (2) react with benzaldehyd e derivatives (4-nitrobenzaldehyde , 2-hydroxy benzaldehyde , 2-b romobenzaldehyde , 4-hydroxybenzaldehyde ,benzaldeh yde ,4- dimethyl amino benzaldehyde, 4-Chlorobenzaldehyde a nd vanillin) to get shiff base (3-10). The cyclizat ion of Shiff base Derivatives (3,4) with α -aminoacid (tryptophan and leucine) Consecutive giv e the corresponding imidazolidine derivatives (11,12),and when cyclization of Shiff b ase Derivative (5) with sodium azide give tetrazole derivative (13). Shiff base Derivatives (6,7,8) react with (It aconic, succinic anhydride and malic anhydride ) Co nsecutive to give oxazepine derivatives (14,15,16) Consecutive. cyclization of Shiff base Derivatives (9,10) with chloroacetylchloride give the corresponding β -lactam (17,18). All this compounds characterized b y means of FT- IR, and some of the compoundes by means 1H-NMR, and 13C-NMR and follow reaction by Rf - TLC and Measur e ment melting point.

http://sacs17.amberton.edu/

rtp slot demo